BENDAMUSTINE IS A SAFE AND EFFECTIVE LYMPHODEPLETION AGENT FOR AXICABTAGENE CILOLEUCEL IN PATIENTS WITH REFRACTORY OR RELAPSED LARGE B-CELL LYMPHOMA

Background Fludarabine in combination with cyclophosphamide (FC) is the standard lymphodepletion regimen for CAR T-cell therapy (CAR T).A national fludarabine shortage in 2022 necessitated the exploration of alternative regimens with lcpl chevrons many centers employing single-agent bendamustine as lymphodepletion despite a lack of clinical safety

Crystallographic texturing enables the design of piezoelectric polycrystals that outperform traditional random polycrystals by exhibiting outstanding piezoelectric properties.In this work, phase-field modeling and computer simulation were employed to study the effect of crystallographic texture on the piezoelectric properties of galaxy whisk ferroe